Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Luteolin is a naturally occurring flavonoid found in various fruits, vegetables, and medicinal herbs. Its use in supporting or treating Parkinson’s Disease (PD) is primarily based on preclinical scientific studies rather than traditional medicine or robust clinical evidence. In vitro and animal studies have demonstrated that luteolin possesses neuroprotective, anti-inflammatory, and antioxidant properties. These properties are relevant to Parkinson’s Disease, a neurodegenerative disorder characterized by dopaminergic neuron loss, oxidative stress, and neuroinflammation.

Key findings from preclinical research suggest that luteolin can mitigate neuronal cell death by inhibiting pro-inflammatory cytokines (such as TNF-α and IL-6) and reducing oxidative stress in neuronal cells. Animal models of PD have shown that luteolin administration may attenuate motor deficits and protect against dopaminergic neuron loss, likely by modulating signaling pathways involved in apoptosis and neuroinflammation (e.g., the Nrf2/ARE and NF-κB pathways). However, these beneficial effects remain limited to laboratory studies.

Currently, there are no large-scale, well-controlled clinical trials evaluating the efficacy or safety of luteolin supplementation in humans with Parkinson’s Disease. Thus, while there is scientific rationale and promising preclinical data, the evidence base is insufficient for strong clinical recommendations. The rating of 2 reflects promising laboratory and animal studies but a lack of translational evidence in humans.

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