Evidence supporting the use of: Magnolol
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnolol, a bioactive compound extracted from the bark of Magnolia officinalis, has attracted interest for its neuroprotective properties, particularly in the context of neurodegenerative diseases like Parkinson's Disease (PD). Scientific studies, primarily preclinical (in vitro and animal models), have demonstrated that magnolol exhibits antioxidant, anti-inflammatory, and antiapoptotic effects, which are believed to be beneficial in mitigating the neuronal damage characteristic of PD. For example, research has shown that magnolol can attenuate dopaminergic neuronal loss by inhibiting microglial activation and reducing oxidative stress in toxin-induced models of PD (Chen et al., 2015; Zhu et al., 2014). Furthermore, magnolol has been reported to modulate signaling pathways associated with cell survival and mitochondrial function, which may offer further neuroprotection.

However, despite these promising preclinical findings, there is currently a lack of robust clinical evidence in humans supporting the efficacy of magnolol as a treatment for Parkinson's Disease. No large-scale randomized controlled trials have been conducted to establish its safety and effectiveness in PD patients. Thus, while the scientific rationale is supported by animal and cellular data, translation to clinical practice is premature. The evidence rating is 2, reflecting promising but early-stage scientific validation.

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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing magnolol

We currently have no products on Vitabase that contain this ingredient.