Evidence supporting the use of: Mangiferin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mangiferin, a polyphenolic compound found primarily in mangoes (Mangifera indica), has garnered interest for its neuroprotective and antioxidant properties. Preclinical studies have investigated its potential benefits for neurodegenerative diseases, including Parkinson’s Disease (PD). Several animal studies suggest that mangiferin may exert neuroprotective effects through multiple mechanisms, such as reduction of oxidative stress, inhibition of neuroinflammation, and mitigation of dopaminergic neuronal loss. For instance, rodent models of PD induced by neurotoxins like MPTP or rotenone have shown that mangiferin administration can reduce behavioral deficits and protect dopaminergic neurons, likely by attenuating oxidative damage and modulating inflammatory pathways (e.g., Nrf2/ARE signaling).

However, as of June 2024, there is no robust clinical evidence in humans to support the use of mangiferin as a treatment or adjunct therapy for Parkinson’s Disease. The evidence remains limited to in vitro and animal studies, which, while promising, are insufficient to justify clinical use. No major traditional medicine systems are documented as using mangiferin or mango extracts specifically for Parkinson’s Disease. In summary, the scientific rationale is based on preclinical findings with a low (2/5) evidence rating, and further research, especially human clinical trials, is needed before mangiferin can be recommended for PD management.

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