Evidence supporting the use of: Mangiferin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mangiferin, a polyphenolic compound found primarily in mangoes (Mangifera indica), has garnered interest for its neuroprotective and antioxidant properties. Preclinical studies have investigated its potential benefits for neurodegenerative diseases, including Parkinson’s Disease (PD). Several animal studies suggest that mangiferin may exert neuroprotective effects through multiple mechanisms, such as reduction of oxidative stress, inhibition of neuroinflammation, and mitigation of dopaminergic neuronal loss. For instance, rodent models of PD induced by neurotoxins like MPTP or rotenone have shown that mangiferin administration can reduce behavioral deficits and protect dopaminergic neurons, likely by attenuating oxidative damage and modulating inflammatory pathways (e.g., Nrf2/ARE signaling).

However, as of June 2024, there is no robust clinical evidence in humans to support the use of mangiferin as a treatment or adjunct therapy for Parkinson’s Disease. The evidence remains limited to in vitro and animal studies, which, while promising, are insufficient to justify clinical use. No major traditional medicine systems are documented as using mangiferin or mango extracts specifically for Parkinson’s Disease. In summary, the scientific rationale is based on preclinical findings with a low (2/5) evidence rating, and further research, especially human clinical trials, is needed before mangiferin can be recommended for PD management.

More about mangiferin
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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
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Products containing mangiferin

We currently have no products on Vitabase that contain this ingredient.