Evidence supporting the use of: Melatonin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Melatonin has been explored as a supplemental treatment in Parkinson’s Disease (PD) primarily due to its role in regulating sleep-wake cycles and its antioxidant properties. Many individuals with PD experience sleep disturbances, including insomnia, REM sleep behavior disorder (RBD), and excessive daytime sleepiness. Several small randomized controlled trials and observational studies have evaluated melatonin's effectiveness in improving sleep quality in PD patients. These studies suggest that melatonin (typically 2–5 mg) can improve subjective sleep quality and reduce symptoms of RBD, a common non-motor symptom in PD characterized by acting out dreams during REM sleep. However, the evidence remains limited by small sample sizes and short study durations. Beyond sleep, preclinical studies (mainly in animal models) have shown that melatonin possesses neuroprotective and antioxidant effects that may theoretically benefit PD by reducing oxidative stress and neuronal degeneration. However, clinical evidence supporting neuroprotective or disease-modifying effects in humans is lacking. Melatonin is generally well-tolerated with a low side-effect profile, making it a reasonable option for addressing sleep disorders in PD, but not as a primary treatment for core motor symptoms or disease progression. In summary, there is modest scientific evidence supporting melatonin's use for sleep-related symptoms in Parkinson’s Disease, but not for altering disease progression. Large, well-controlled clinical trials are needed to clarify its role further.

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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)