Evidence supporting the use of: Myricetin
For the health condition: Parkinson's Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Myricetin is a natural flavonoid found in many fruits, vegetables, and plants. Its potential use for Parkinson’s Disease (PD) is supported by preclinical scientific evidence, primarily from in vitro (cell culture) and animal studies. Research indicates that myricetin possesses strong antioxidant and anti-inflammatory properties, both of which are relevant to the pathogenesis of PD, a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Several studies have demonstrated that myricetin can protect neuronal cells from oxidative stress-induced apoptosis and may inhibit neuroinflammation by modulating signaling pathways such as NF-κB.
Animal model studies have shown that myricetin administration can attenuate motor deficits and neuronal loss in models of PD induced by toxins like MPTP or 6-OHDA. The protective effects are believed to result from its ability to scavenge reactive oxygen species, reduce lipid peroxidation, and modulate apoptotic pathways. However, there are currently no robust clinical trials in humans to validate these findings, and myricetin is not an approved or standard treatment for Parkinson’s Disease. Thus, while there is preliminary scientific rationale, the evidence is limited to preclinical studies, and more research is needed to establish safety and efficacy in humans.
Other ingredients used for Parkinson's Disease
1,3,7-Trimethylpurine-2,6-dione7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)