Synopsis

Source of validity: Scientific
Rating (out of 5): 2

NADH (nicotinamide adenine dinucleotide + hydrogen) has been investigated as a potential treatment for Parkinson’s Disease (PD) due to its role in cellular energy metabolism and mitochondrial function. The rationale is based on evidence that mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of PD. Several small clinical studies, primarily from the 1990s and early 2000s, have explored the efficacy of NADH supplementation in improving symptoms of PD. Some open-label and uncontrolled studies reported mild to moderate symptomatic improvements, particularly in motor function, when patients received intravenous or oral NADH. However, these studies were limited by small sample sizes, lack of blinding, and short duration. A few randomized controlled trials exist, but the results have been inconsistent, and the overall quality of evidence is low. Major neurological and movement disorder societies do not currently endorse NADH as a standard therapy for PD, citing insufficient robust clinical evidence. In summary, while there is a scientific rationale and some preliminary clinical research supporting the use of NADH in Parkinson's Disease, the evidence is limited and of low quality, resulting in a low confidence rating for its effectiveness.

More about NADH
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Other health conditions supported by NADH

Alzheimer's Disease
Fatigue
Memory and Brain Function
Parkinson's Disease

Products containing NADH

We currently have no products on Vitabase that contain this ingredient.