Evidence supporting the use of: Palmitoylethanolamide (PEA)
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide that has been studied for its anti-inflammatory and neuroprotective properties. There is emerging, but limited, scientific interest in the use of PEA to support or treat Parkinson's Disease (PD). Preclinical studies in animal models of PD indicate that PEA can reduce neuroinflammation and may protect dopaminergic neurons from degeneration, which are key factors in the pathology of PD. Some small human studies and case reports suggest that PEA supplementation may improve certain symptoms of PD, such as pain and rigidity, possibly via its effects on non-neuronal cells (glia) and modulation of the endocannabinoid system.

However, clinical evidence is currently sparse. Randomized controlled trials in humans are lacking, and most available data come from preliminary or open-label studies with small sample sizes and short durations. As a result, while PEA has a plausible scientific rationale and some promising early results, the overall evidence supporting its use in Parkinson's Disease remains weak and inconclusive. Larger, well-designed clinical trials are needed to establish efficacy and safety. Thus, PEA should not be considered a standard or primary treatment for PD, but rather an experimental adjunct under medical supervision.

More about Palmitoylethanolamide (PEA)
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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing Palmitoylethanolamide (PEA)

We currently have no products on Vitabase that contain this ingredient.