Evidence supporting the use of: Panax Ginseng
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Panax ginseng has been investigated in preclinical and limited clinical settings for its potential neuroprotective effects in Parkinson’s Disease (PD). Most evidence comes from animal studies and in vitro experiments, which suggest that ginsenosides, the active constituents of Panax ginseng, may exert antioxidative, anti-inflammatory, and anti-apoptotic effects on dopaminergic neurons. These effects could theoretically attenuate neuronal loss characteristic of Parkinson’s pathology. Several rodent studies have demonstrated that Panax ginseng extracts or specific ginsenosides (e.g., Rg1, Rb1) can reduce neurotoxicity induced by agents like MPTP or 6-OHDA, which are models for PD. There are also reports that ginseng may modulate mitochondrial function and inhibit microglial activation, potentially offering further neuroprotection. However, robust clinical data in humans are lacking. Only a few small-scale clinical trials or case reports have explored Panax ginseng for PD, with mixed or inconclusive results. No large, well-controlled clinical trials have established its efficacy or safety for PD management. Thus, while the scientific rationale is supported by preclinical research, the overall evidence remains preliminary and insufficient for strong clinical recommendations. Panax ginseng is not a standard or approved therapy for Parkinson’s Disease, and further research is needed to clarify its role, if any, in this context.

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