Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidylserine (PS) is a phospholipid found in high concentrations in brain cell membranes and is thought to play a role in neuronal signaling and cognitive function. Its use in Parkinson's Disease (PD) is primarily based on scientific exploration rather than long-standing traditional use. Several small clinical studies from the 1980s and 1990s suggested that phosphatidylserine supplementation might improve some cognitive symptoms in elderly patients with dementia or cognitive decline, including those with Parkinson’s-related dementia. For example, a double-blind trial by Cenacchi et al. (1987) observed mild improvements in memory and daily functioning in PD patients given PS. However, these studies had limitations such as small sample sizes, short durations, and often lacked rigorous modern methodology.

A few animal studies have also indicated that phosphatidylserine may have neuroprotective effects or enhance dopaminergic activity, which is relevant to PD. However, large, high-quality randomized controlled trials in humans with Parkinson’s disease are lacking, and systematic reviews typically conclude that evidence is insufficient to recommend PS as a treatment for PD symptoms. As of 2024, scientific validation remains weak, with current guidelines not recommending phosphatidylserine as a standard therapy for Parkinson’s Disease. While PS is considered safe and is available as an over-the-counter supplement, its role in Parkinson’s Disease management is not strongly supported by robust clinical evidence.

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