Evidence supporting the use of: Phytocannabinoid (unspecified)
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phytocannabinoids—primarily cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC)—have been investigated for their potential to alleviate symptoms of Parkinson's Disease (PD). The rationale stems from the modulation of the endocannabinoid system, which is implicated in motor control and neuroprotection. Several small clinical trials and observational studies have evaluated the effects of cannabinoids on PD symptoms such as tremor, rigidity, bradykinesia, and non-motor symptoms like sleep disturbances and psychosis.

Results to date are mixed. Some studies report minor improvements in quality of life, sleep, or reduction in dyskinesias (involuntary movements), while others find no significant effect on primary motor symptoms. The evidence base is limited by small sample sizes, lack of standardized formulations or dosing, and short study durations. Systematic reviews and meta-analyses (e.g., Kluger et al., 2021, JAMA Neurology; Ferreira et al., 2020, Movement Disorders) consistently conclude that there is insufficient high-quality evidence to support routine use, though research remains ongoing. Safety profiles are generally acceptable but may include sedation, cognitive changes, or psychosis, particularly with THC.

In summary, phytocannabinoids are being scientifically investigated for PD, but the current evidence supporting their use is weak (rated 2/5), and major neurology guidelines do not recommend them as standard treatment. Their use is thus justified by preliminary scientific research rather than tradition or robust clinical evidence.

More about Phytocannabinoid (unspecified)
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Phytocannabinoid (unspecified)

We currently have no products on Vitabase that contain this ingredient.