Evidence supporting the use of: Puerain
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Puerarin is an isoflavone compound extracted from the root of Pueraria lobata (kudzu). It has a long history of use in traditional Chinese medicine, primarily for cardiovascular and neurological conditions. In relation to Parkinson’s Disease (PD), there is some emerging scientific interest. Preclinical studies, mostly in animal models and cell cultures, suggest that puerarin exhibits neuroprotective properties, possibly through antioxidative, anti-inflammatory, and anti-apoptotic mechanisms. For instance, several studies have shown that puerarin can attenuate dopaminergic neuronal loss in toxin-induced PD models, reduce oxidative stress markers, and modulate signaling pathways involved in cell survival. However, these findings are preliminary, and there is a lack of robust clinical trials in humans. While the animal data is promising and suggests a potential role for puerarin in slowing PD progression or alleviating symptoms, clinical efficacy and safety remain unproven. Consequently, although there is a scientific rationale and preclinical evidence for its use, the strength of evidence is low (rated 2/5), and puerarin should not be considered a validated or established therapy for Parkinson’s Disease at this time. More rigorous human studies are needed to determine its real-world benefit and safety profile in PD patients.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Puerain

We currently have no products on Vitabase that contain this ingredient.