Evidence supporting the use of: Puerarin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Puerarin is an isoflavone derived from the root of Pueraria lobata (kudzu), a plant widely used in traditional Chinese medicine. While its use in Parkinson's disease (PD) is not rooted in traditional practices specifically for this condition, there is a growing body of preclinical scientific research exploring its neuroprotective potential. Several animal and in vitro studies have suggested that puerarin can exert beneficial effects in models of neurodegenerative diseases, including PD. These effects are believed to be mediated through mechanisms such as antioxidation, anti-inflammation, inhibition of apoptosis, and modulation of neurotransmitter systems. For example, studies in rodent models of PD induced by neurotoxins (like MPTP or 6-OHDA) have shown that puerarin administration may reduce dopaminergic neuron loss, improve motor function, and decrease markers of oxidative stress and inflammation in the brain.

However, evidence from human clinical trials is lacking, and no major clinical guidelines endorse puerarin as a treatment for PD. The current support for its use is thus primarily based on experimental models rather than clinical efficacy. The overall quality of evidence is low (rated 2/5), mainly due to the lack of direct human data. While the preliminary findings are promising, further research—including well-designed clinical trials—is needed to establish the safety and efficacy of puerarin in the management of Parkinson's disease.

More about Puerarin
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing Puerarin

We currently have no products on Vitabase that contain this ingredient.