Evidence supporting the use of: Pyrroloquinoline Quinone
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Pyrroloquinoline quinone (PQQ) is a redox cofactor and antioxidant found in some foods and studied for its neuroprotective properties. Its use in Parkinson’s Disease (PD) is based on preclinical studies demonstrating antioxidant, mitochondrial-supporting, and neuroprotective effects. In animal models of PD, PQQ has been shown to reduce oxidative stress, limit neuronal damage, and preserve mitochondrial function—mechanisms implicated in PD pathogenesis. For example, some rodent studies indicate that PQQ can attenuate neurotoxicity and motor deficits induced by toxins such as MPTP, which is used to model PD in animals (J Neurosci Res. 2013;91(12):1709-1719). PQQ’s ability to modulate cell signaling and reduce inflammation also supports a theoretical benefit in neurodegenerative conditions. However, no robust clinical trials in humans with PD have been published as of mid-2024. There is no evidence from controlled human studies to confirm efficacy or safety of PQQ for this condition. Thus, while there is some preclinical scientific rationale and animal data, the strength of evidence is rated low, and PQQ should not be considered a proven treatment or support for Parkinson’s Disease.

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