Evidence supporting the use of: Pyrroloquinoline Quinone
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Pyrroloquinoline quinone (PQQ) is a redox cofactor and antioxidant found in some foods and studied for its neuroprotective properties. Its use in Parkinson’s Disease (PD) is based on preclinical studies demonstrating antioxidant, mitochondrial-supporting, and neuroprotective effects. In animal models of PD, PQQ has been shown to reduce oxidative stress, limit neuronal damage, and preserve mitochondrial function—mechanisms implicated in PD pathogenesis. For example, some rodent studies indicate that PQQ can attenuate neurotoxicity and motor deficits induced by toxins such as MPTP, which is used to model PD in animals (J Neurosci Res. 2013;91(12):1709-1719). PQQ’s ability to modulate cell signaling and reduce inflammation also supports a theoretical benefit in neurodegenerative conditions. However, no robust clinical trials in humans with PD have been published as of mid-2024. There is no evidence from controlled human studies to confirm efficacy or safety of PQQ for this condition. Thus, while there is some preclinical scientific rationale and animal data, the strength of evidence is rated low, and PQQ should not be considered a proven treatment or support for Parkinson’s Disease.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Pyrroloquinoline Quinone

We currently have no products on Vitabase that contain this ingredient.