Evidence supporting the use of: Pyrroloquinoline quinone
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Pyrroloquinoline quinone (PQQ) is a redox cofactor and antioxidant found in some foods and studied for its neuroprotective properties. Its use in Parkinson’s Disease (PD) is based on preclinical studies demonstrating antioxidant, mitochondrial-supporting, and neuroprotective effects. In animal models of PD, PQQ has been shown to reduce oxidative stress, limit neuronal damage, and preserve mitochondrial function—mechanisms implicated in PD pathogenesis. For example, some rodent studies indicate that PQQ can attenuate neurotoxicity and motor deficits induced by toxins such as MPTP, which is used to model PD in animals (J Neurosci Res. 2013;91(12):1709-1719). PQQ’s ability to modulate cell signaling and reduce inflammation also supports a theoretical benefit in neurodegenerative conditions. However, no robust clinical trials in humans with PD have been published as of mid-2024. There is no evidence from controlled human studies to confirm efficacy or safety of PQQ for this condition. Thus, while there is some preclinical scientific rationale and animal data, the strength of evidence is rated low, and PQQ should not be considered a proven treatment or support for Parkinson’s Disease.

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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
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Products containing pyrroloquinoline quinone

We currently have no products on Vitabase that contain this ingredient.