Evidence supporting the use of: Salidroside
For the health condition: Parkinson's Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Salidroside, a bioactive compound extracted from Rhodiola rosea, has garnered scientific interest for its potential neuroprotective properties, particularly relevant to neurodegenerative diseases like Parkinson's Disease (PD). Preclinical studies—primarily in cell cultures and animal models—have demonstrated that salidroside can exert antioxidant, anti-apoptotic, and anti-inflammatory effects. These actions are significant in the context of PD, which is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra, largely driven by oxidative stress and mitochondrial dysfunction.

Several studies have shown that salidroside administration reduces neuronal death, inhibits mitochondrial dysfunction, and suppresses inflammatory pathways in models of PD induced by toxins such as MPTP or 6-OHDA. For example, a 2013 study in Neuroscience Letters showed that salidroside protected dopaminergic neurons and improved behavioral outcomes in MPTP-lesioned mice. Mechanistically, these effects are attributed to activation of the PI3K/Akt pathway and upregulation of endogenous antioxidant defenses.

However, despite encouraging preclinical data, there is a lack of robust clinical trials in humans evaluating salidroside’s efficacy and safety for PD. Thus, while there is some scientific rationale and early evidence, its use for Parkinson’s Disease remains experimental and cannot be considered evidence-based therapy at this time.

More about Salidroside
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing Salidroside

We currently have no products on Vitabase that contain this ingredient.