Evidence supporting the use of: Salidroside
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Salidroside, a bioactive compound extracted from Rhodiola rosea, has garnered scientific interest for its potential neuroprotective properties, particularly relevant to neurodegenerative diseases like Parkinson's Disease (PD). Preclinical studies—primarily in cell cultures and animal models—have demonstrated that salidroside can exert antioxidant, anti-apoptotic, and anti-inflammatory effects. These actions are significant in the context of PD, which is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra, largely driven by oxidative stress and mitochondrial dysfunction.

Several studies have shown that salidroside administration reduces neuronal death, inhibits mitochondrial dysfunction, and suppresses inflammatory pathways in models of PD induced by toxins such as MPTP or 6-OHDA. For example, a 2013 study in Neuroscience Letters showed that salidroside protected dopaminergic neurons and improved behavioral outcomes in MPTP-lesioned mice. Mechanistically, these effects are attributed to activation of the PI3K/Akt pathway and upregulation of endogenous antioxidant defenses.

However, despite encouraging preclinical data, there is a lack of robust clinical trials in humans evaluating salidroside’s efficacy and safety for PD. Thus, while there is some scientific rationale and early evidence, its use for Parkinson’s Disease remains experimental and cannot be considered evidence-based therapy at this time.

More about Salidroside
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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Salidroside

We currently have no products on Vitabase that contain this ingredient.