Evidence supporting the use of: Spirulina
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Spirulina, a blue-green algae, has garnered scientific interest for its potential neuroprotective effects, including possible benefits in Parkinson's Disease (PD). Preclinical studies in animal models have shown that spirulina possesses antioxidant and anti-inflammatory properties, which are relevant because oxidative stress and neuroinflammation contribute to the degeneration of dopaminergic neurons in PD. Several rodent studies have demonstrated that supplementation with spirulina may reduce neuronal loss and improve motor function in toxin-induced models of Parkinson’s Disease. For example, research published in journals such as Neurobiology of Disease has shown that diets enriched with spirulina can attenuate neurodegeneration and modulate microglial activation in animal models.

Despite these promising findings, there is a lack of robust clinical evidence in humans. No large-scale, well-controlled clinical trials have been conducted to confirm efficacy or safety of spirulina for patients with PD. The bulk of the current evidence is limited to laboratory and animal studies, which do not always translate to human benefits. As such, while the scientific rationale for using spirulina in Parkinson’s Disease is grounded in mechanistic and preclinical data, the overall evidence supporting its use in humans is weak (rated 2/5). Patients should consult healthcare providers before using spirulina as a complementary therapy.

More about spirulina
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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)