Evidence supporting the use of: Sulforaphane
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulforaphane, a compound found in cruciferous vegetables like broccoli, has been investigated for its potential neuroprotective effects, including in the context of Parkinson’s Disease (PD). Preclinical studies—primarily in cell culture and animal models—suggest that sulforaphane activates the Nrf2 pathway, which enhances cellular antioxidant defenses and may reduce neuroinflammation and oxidative stress, both implicated in PD pathogenesis. For example, research has shown that sulforaphane can protect dopaminergic neurons from toxin-induced damage in rodent models of PD, possibly by upregulating detoxifying enzymes and reducing the accumulation of reactive oxygen species.

However, as of June 2024, there are no published clinical trials demonstrating efficacy or safety of sulforaphane supplementation in humans with Parkinson’s Disease. The evidence supporting its use is thus limited to laboratory studies, which, while promising, do not guarantee similar effects in human patients. There is also no tradition of sulforaphane-rich foods or extracts being used specifically for Parkinson’s in historical or alternative medical systems. Overall, scientific interest in sulforaphane for PD is based on mechanistic rationale and preclinical results, but robust human evidence is lacking, resulting in a moderate-to-low evidence rating.

More about Sulforaphane
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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Sulforaphane

We currently have no products on Vitabase that contain this ingredient.