Evidence supporting the use of: Sulforaphane
For the health condition: Parkinson's Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulforaphane, a compound found in cruciferous vegetables like broccoli, has been investigated for its potential neuroprotective effects, including in the context of Parkinson’s Disease (PD). Preclinical studies—primarily in cell culture and animal models—suggest that sulforaphane activates the Nrf2 pathway, which enhances cellular antioxidant defenses and may reduce neuroinflammation and oxidative stress, both implicated in PD pathogenesis. For example, research has shown that sulforaphane can protect dopaminergic neurons from toxin-induced damage in rodent models of PD, possibly by upregulating detoxifying enzymes and reducing the accumulation of reactive oxygen species.

However, as of June 2024, there are no published clinical trials demonstrating efficacy or safety of sulforaphane supplementation in humans with Parkinson’s Disease. The evidence supporting its use is thus limited to laboratory studies, which, while promising, do not guarantee similar effects in human patients. There is also no tradition of sulforaphane-rich foods or extracts being used specifically for Parkinson’s in historical or alternative medical systems. Overall, scientific interest in sulforaphane for PD is based on mechanistic rationale and preclinical results, but robust human evidence is lacking, resulting in a moderate-to-low evidence rating.

More about Sulforaphane
More about Parkinson's Disease

Products containing Sulforaphane

We currently have no products on Vitabase that contain this ingredient.