Evidence supporting the use of: Sulforaphane
For the health condition: Parkinson's Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulforaphane, a compound found in cruciferous vegetables like broccoli, has been investigated for its potential neuroprotective effects, including in the context of Parkinson’s Disease (PD). Preclinical studies—primarily in cell culture and animal models—suggest that sulforaphane activates the Nrf2 pathway, which enhances cellular antioxidant defenses and may reduce neuroinflammation and oxidative stress, both implicated in PD pathogenesis. For example, research has shown that sulforaphane can protect dopaminergic neurons from toxin-induced damage in rodent models of PD, possibly by upregulating detoxifying enzymes and reducing the accumulation of reactive oxygen species.

However, as of June 2024, there are no published clinical trials demonstrating efficacy or safety of sulforaphane supplementation in humans with Parkinson’s Disease. The evidence supporting its use is thus limited to laboratory studies, which, while promising, do not guarantee similar effects in human patients. There is also no tradition of sulforaphane-rich foods or extracts being used specifically for Parkinson’s in historical or alternative medical systems. Overall, scientific interest in sulforaphane for PD is based on mechanistic rationale and preclinical results, but robust human evidence is lacking, resulting in a moderate-to-low evidence rating.

More about Sulforaphane
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing Sulforaphane

We currently have no products on Vitabase that contain this ingredient.