Evidence supporting the use of: Sulforophane
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulforaphane, a compound found in cruciferous vegetables like broccoli, has been investigated for its neuroprotective properties, particularly in relation to Parkinson's Disease (PD). The scientific interest centers on sulforaphane's ability to activate the Nrf2 pathway, which upregulates the expression of antioxidant and cytoprotective genes. Preclinical studies using cellular and animal models of PD have demonstrated that sulforaphane can attenuate oxidative stress, reduce neuroinflammation, and protect dopaminergic neurons from degeneration induced by toxins such as MPTP and 6-hydroxydopamine. These findings suggest a potential therapeutic role for sulforaphane in slowing the progression of neuronal damage associated with PD. However, as of mid-2024, there is insufficient clinical evidence to support the use of sulforaphane in human PD patients. No large-scale, peer-reviewed clinical trials have demonstrated efficacy or safety for this indication. The majority of data comes from in vitro and animal studies, which, while promising, do not always translate to human benefit. Therefore, while the use of sulforaphane for PD is based on plausible biological mechanisms and preclinical evidence, its application in clinical practice remains experimental. Patients and clinicians should await results from well-designed human trials before considering sulforaphane as a therapeutic option for Parkinson’s Disease.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
Melatonin
N-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
apigenin
Agmatine
astragalin
biopterin
baicalein
brahmi
broad bean
bacoside
baicalin
catalpol
creatine
C-phycocyanin
cannabidiol
carnosic acid
decarboxylase
ergothioneine
eicosapentaenoic acid
fo-ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
gastrodin
Haematococcus pluvialis
Honokiol
hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
mangiferin
Myricetin
magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
pyrroloquinoline quinone
Puerarin
paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
Trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Sulforophane

We currently have no products on Vitabase that contain this ingredient.