Evidence supporting the use of: Tanshinone
For the health condition: Parkinson's Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tanshinone is a class of bioactive compounds derived from the roots of Salvia miltiorrhiza (Danshen), a traditional Chinese medicinal herb. In recent years, tanshinones—particularly tanshinone I and tanshinone IIA—have been investigated in preclinical studies for their neuroprotective effects, including their potential in models of Parkinson's Disease (PD). Laboratory and animal studies suggest that tanshinones may exert beneficial effects through several mechanisms relevant to PD: antioxidative stress, anti-inflammatory activity, mitochondrial protection, inhibition of neuronal apoptosis, and modulation of dopaminergic neuron survival. However, the evidence supporting the use of tanshinones in PD is currently limited to in vitro studies and animal models. For example, some studies have reported that tanshinone IIA can attenuate dopaminergic neuron loss and reduce oxidative damage in rodent models of PD induced by 6-hydroxydopamine (6-OHDA) or MPTP. These findings suggest a potential neuroprotective effect, but no high-quality clinical trials in humans have been published to confirm efficacy or safety for PD patients. In summary, while there is a scientific rationale and early experimental support for investigating tanshinones in Parkinson’s Disease, the evidence is preliminary and does not yet justify clinical use. Further research, including well-controlled human studies, is needed before tanshinones can be recommended for this indication.

More about Tanshinone
More about Parkinson's Disease

Products containing Tanshinone

We currently have no products on Vitabase that contain this ingredient.