Evidence supporting the use of: Trehalose
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trehalose is a naturally occurring disaccharide sugar that has attracted scientific interest for its potential neuroprotective properties, particularly in neurodegenerative diseases like Parkinson’s Disease (PD). Research over the past decade has focused on its ability to enhance autophagy—a process that helps clear misfolded proteins and damaged organelles from cells. In PD, the accumulation of misfolded alpha-synuclein proteins is a hallmark pathology, and impaired autophagy is thought to contribute to disease progression.

Preclinical studies in cell cultures and animal models have demonstrated that trehalose can induce autophagy and reduce the accumulation of alpha-synuclein aggregates, thus providing a protective effect against neuronal death. For example, some studies in mouse models of PD found that oral administration of trehalose improved motor function and reduced neuropathology. However, most of the evidence remains at the preclinical stage; there are currently no large-scale, high-quality human clinical trials demonstrating that trehalose supplementation has a clear, significant benefit for people with PD.

Therefore, while there is a scientific rationale and some preliminary preclinical evidence supporting the use of trehalose in Parkinson’s Disease, the evidence is limited and not yet conclusive. The clinical relevance, optimal dosing, and long-term safety in humans have yet to be established.

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