Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trehalose is a naturally occurring disaccharide sugar that has attracted scientific interest for its potential neuroprotective properties, particularly in neurodegenerative diseases like Parkinson’s Disease (PD). Research over the past decade has focused on its ability to enhance autophagy—a process that helps clear misfolded proteins and damaged organelles from cells. In PD, the accumulation of misfolded alpha-synuclein proteins is a hallmark pathology, and impaired autophagy is thought to contribute to disease progression.

Preclinical studies in cell cultures and animal models have demonstrated that trehalose can induce autophagy and reduce the accumulation of alpha-synuclein aggregates, thus providing a protective effect against neuronal death. For example, some studies in mouse models of PD found that oral administration of trehalose improved motor function and reduced neuropathology. However, most of the evidence remains at the preclinical stage; there are currently no large-scale, high-quality human clinical trials demonstrating that trehalose supplementation has a clear, significant benefit for people with PD.

Therefore, while there is a scientific rationale and some preliminary preclinical evidence supporting the use of trehalose in Parkinson’s Disease, the evidence is limited and not yet conclusive. The clinical relevance, optimal dosing, and long-term safety in humans have yet to be established.

More about Trehalose
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Other health conditions supported by Trehalose

Alzheimer's Disease
Dementia
Fatty Liver Disease
Inflammation
Parkinson's Disease

Products containing Trehalose

We currently have no products on Vitabase that contain this ingredient.