Evidence supporting the use of: Turmerone
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Turmerone, a bioactive compound found in turmeric (Curcuma longa), has been investigated for its potential neuroprotective effects, including possible benefits in neurodegenerative diseases such as Parkinson's Disease (PD). Preclinical research, primarily in cell culture and animal models, has shown that turmerone may promote neural stem cell proliferation and differentiation, which could theoretically aid in the regeneration of dopaminergic neurons lost in PD. Additionally, turmerone exhibits anti-inflammatory and antioxidant properties, which may help counteract some of the neuroinflammatory processes implicated in Parkinson’s pathology.

However, the evidence supporting turmerone’s use for Parkinson’s Disease is currently limited to preclinical studies. For example, a 2014 study published in Stem Cell Research & Therapy reported that turmerone increased neural stem cell proliferation in rodents. Other studies have noted protective effects against neurotoxicity in cell models exposed to Parkinsonian toxins. Despite these promising findings, there have been no robust clinical trials in humans evaluating turmerone as a therapy for Parkinson’s Disease. Consequently, while the scientific rationale exists, the evidence base is still preliminary and does not yet justify clinical recommendations.

In summary, the use of turmerone for Parkinson’s Disease is supported by early-stage scientific research, but there is a lack of high-quality human data. Further studies, particularly clinical trials, are necessary to establish efficacy and safety in this context.

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