Evidence supporting the use of: Velvet bean
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Velvet bean (Mucuna pruriens) has a long history of use in traditional Ayurvedic medicine for neurological disorders, including symptoms resembling Parkinson’s Disease (PD). The scientific rationale for its use in modern times is based on its high natural content of levodopa (L-dopa), the same compound used as a cornerstone therapy in conventional PD treatment. L-dopa is a precursor to dopamine, a neurotransmitter that becomes deficient in the brains of those with Parkinson’s Disease.

A number of clinical studies have investigated the efficacy of Mucuna pruriens seed preparations in PD. In a randomized, controlled, double-blind crossover trial (2004), patients with PD were given either standard levodopa or a dose-equivalent Mucuna extract. The Mucuna group had a faster onset of action and a longer duration of clinical benefit, with no significant increase in adverse effects. Several smaller trials and case reports have also found that velvet bean can reduce movement symptoms and may have a lower risk of some complications such as dyskinesias, though more research is needed.

While there is scientific validation for its efficacy—largely attributed to its L-dopa content—standardization, dosing, and long-term safety remain concerns. Nevertheless, both traditional use and modern studies support velvet bean as a viable, albeit alternative, option for PD management, especially where pharmaceutical L-dopa is unavailable or unaffordable.

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butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
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green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
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N-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
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vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
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7,8-Dihydroxyflavone
apigenin
Agmatine
astragalin
biopterin
baicalein
brahmi
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bacoside
baicalin
catalpol
creatine
C-phycocyanin
cannabidiol
carnosic acid
decarboxylase
ergothioneine
eicosapentaenoic acid
fo-ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
gastrodin
Haematococcus pluvialis
Honokiol
hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
mangiferin
Myricetin
magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
pyrroloquinoline quinone
Puerarin
paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
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