Evidence supporting the use of: Vitamin D (cholecalciferol)
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D (cholecalciferol) has attracted scientific interest for its potential role in supporting patients with Parkinson's Disease (PD), though evidence remains limited and inconclusive. Several observational studies have found that people with PD often have lower serum vitamin D levels compared to healthy controls. This has prompted hypotheses that vitamin D deficiency may contribute to the progression or severity of PD, given vitamin D’s neuroprotective, anti-inflammatory, and immunomodulatory properties.

Some small interventional studies and pilot trials have examined vitamin D supplementation in PD. For example, a 2013 randomized controlled trial (RCT) by Suzuki et al. suggested that vitamin D supplementation (1200 IU/day) might slow the progression of motor symptoms in PD patients with certain genetic backgrounds. Other trials, however, have failed to show significant benefit for motor or cognitive outcomes in the general PD population. Meta-analyses generally conclude that current evidence does not support a strong effect of vitamin D supplementation on disease progression or symptom management in PD, though it may help address general bone health and reduce fall risk in this population.

Overall, while vitamin D is commonly recommended to PD patients for bone health, its use specifically for neuroprotection or symptom management in PD is based on weak scientific evidence (rated 2/5). Large, high-quality clinical trials are needed to clarify any potential benefits.

More about Vitamin D (cholecalciferol)
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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Vitamin D (cholecalciferol)

We currently have no products on Vitabase that contain this ingredient.