Evidence supporting the use of: Vitamin D (cholecalciferol)
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D (cholecalciferol) has attracted scientific interest for its potential role in supporting patients with Parkinson's Disease (PD), though evidence remains limited and inconclusive. Several observational studies have found that people with PD often have lower serum vitamin D levels compared to healthy controls. This has prompted hypotheses that vitamin D deficiency may contribute to the progression or severity of PD, given vitamin D’s neuroprotective, anti-inflammatory, and immunomodulatory properties.

Some small interventional studies and pilot trials have examined vitamin D supplementation in PD. For example, a 2013 randomized controlled trial (RCT) by Suzuki et al. suggested that vitamin D supplementation (1200 IU/day) might slow the progression of motor symptoms in PD patients with certain genetic backgrounds. Other trials, however, have failed to show significant benefit for motor or cognitive outcomes in the general PD population. Meta-analyses generally conclude that current evidence does not support a strong effect of vitamin D supplementation on disease progression or symptom management in PD, though it may help address general bone health and reduce fall risk in this population.

Overall, while vitamin D is commonly recommended to PD patients for bone health, its use specifically for neuroprotection or symptom management in PD is based on weak scientific evidence (rated 2/5). Large, high-quality clinical trials are needed to clarify any potential benefits.

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