Evidence supporting the use of: Vitamin D (mixed)
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has been investigated for its potential role in supporting patients with Parkinson's Disease (PD). Several observational studies have reported that individuals with PD often have lower serum vitamin D levels compared to healthy controls, and low vitamin D status has been associated with increased risk of developing PD and with greater severity of motor symptoms. The biological rationale centers on vitamin D’s roles in neuroprotection, regulation of calcium homeostasis, reduction of neuroinflammation, and modulation of immune response—mechanisms that may be relevant in the pathogenesis and progression of PD.

However, the evidence for clinical benefit is limited. Randomized controlled trials (RCTs) have been few and generally small. A 2013 RCT (Suzuki et al.) found that vitamin D supplementation slowed the progression of motor symptoms in early PD, but subsequent studies have not consistently replicated these findings. Systematic reviews and meta-analyses conclude that while vitamin D deficiency is common in PD and may be associated with worse outcomes, there is insufficient high-quality evidence to recommend supplementation specifically for PD symptom treatment or progression. Current guidelines do not endorse vitamin D as a disease-modifying therapy for PD, though correcting deficiency is considered good general practice for bone and overall health. Thus, scientific interest exists, but robust validation is lacking.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Vitamin D (mixed)

We currently have no products on Vitabase that contain this ingredient.