Evidence supporting the use of: Vitexin
For the health condition: Parkinson's Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Vitexin is a naturally occurring flavonoid glycoside found in various medicinal plants, such as Passiflora incarnata and Hawthorn species. Recent scientific interest has focused on its potential neuroprotective effects, including application to neurodegenerative disorders like Parkinson’s Disease (PD). Preclinical studies, primarily conducted in cellular and animal models, suggest that Vitexin may exert protective effects on dopaminergic neurons. These effects are often attributed to its antioxidant, anti-inflammatory, and anti-apoptotic properties. For instance, several studies have demonstrated that Vitexin can reduce oxidative stress, inhibit neuroinflammation, and modulate signaling pathways involved in neuronal survival, such as the PI3K/Akt pathway. These mechanisms are relevant because oxidative stress and neuroinflammation are key contributors to the progression of PD. However, it is important to note that, as of 2024, there are no published clinical trials evaluating the efficacy or safety of Vitexin in human patients with Parkinson’s Disease. The evidence is limited to laboratory research, and there is no regulatory approval or guideline recommendation for its use in PD. Therefore, while there is some scientific basis for considering Vitexin as a candidate for neuroprotection in Parkinson’s Disease, the evidence remains preliminary (rated 2/5), and further research, especially well-designed human studies, is necessary before its use can be supported in clinical practice.
Other ingredients used for Parkinson's Disease
1,3,7-Trimethylpurine-2,6-dione7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)