Relationship: Peripheral Neuropathy and coenzyme Q10 (CoQ10)

Evidence supporting the use of: Coenzyme Q10 (CoQ10)
For the health condition: Peripheral Neuropathy

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Source of validity: Scientific
Rating (out of 5): 2

Coenzyme Q10 (CoQ10) is used to support or treat peripheral neuropathy primarily based on scientific rationale and emerging, though limited, clinical evidence. CoQ10 is a naturally occurring antioxidant that plays a crucial role in mitochondrial function and cellular energy production. Peripheral neuropathy, which involves damage or dysfunction of the peripheral nerves, is often associated with oxidative stress and mitochondrial dysfunction. This has prompted interest in antioxidants like CoQ10 as potential therapeutic agents. Some small-scale clinical studies and animal experiments suggest that CoQ10 may help reduce neuropathic symptoms by improving nerve function and reducing oxidative damage. For example, a few randomized controlled trials (RCTs) and pilot studies have examined CoQ10 supplementation in patients with diabetic neuropathy, showing modest improvements in pain scores, nerve conduction, and certain biomarkers of oxidative stress. Additionally, preclinical studies in animal models of neuropathy have demonstrated protective effects of CoQ10 on nerve tissue. However, the overall quality and quantity of evidence remain low. Most studies are small, of short duration, and sometimes lack rigorous controls. Large-scale, well-designed RCTs are lacking, and major clinical guidelines do not recommend CoQ10 as a standard treatment for peripheral neuropathy. In summary, while there is a plausible scientific rationale and some preliminary positive findings, the evidence supporting CoQ10’s use for peripheral neuropathy is limited and not yet robust.

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Evidence supporting the use of: Coenzyme Q10 (CoQ10)
For the health condition: Peripheral Neuropathy

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Evidence supporting the use of: Coenzyme Q10 (CoQ10)For the health condition: Peripheral Neuropathy

Table of Contents

Synopsis

Other ingredients used for Peripheral Neuropathy

Other health conditions supported by coenzyme Q10 (CoQ10)

Products containing coenzyme Q10 (CoQ10)

Evidence supporting the use of: Coenzyme Q10 (CoQ10)
For the health condition: Peripheral Neuropathy