Evidence supporting the use of: Ginkgo Falvone Glycoside
For the health condition: Peripheral Neuropathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginkgo flavone glycosides, the active constituents of Ginkgo biloba extract, have been investigated in several clinical and preclinical studies for their potential benefit in peripheral neuropathy, especially diabetic neuropathy. The rationale for their use is based on Ginkgo’s vasoregulatory, neuroprotective, and antioxidant properties. Some animal studies have demonstrated that Ginkgo extract can reduce nerve damage and improve nerve conduction in models of diabetic neuropathy, possibly by decreasing oxidative stress and improving microcirculation. Small-scale human trials and observational studies, mostly conducted in China, suggest that Ginkgo preparations may provide symptomatic relief—reducing numbness, tingling, and pain—in patients with diabetic or chemotherapy-induced neuropathy, although these studies often suffer from limited sample sizes and methodological weaknesses.

A few randomized controlled trials have combined Ginkgo extract with other agents (such as mecobalamin) and reported better outcomes than control groups; however, it is difficult to attribute the benefit solely to Ginkgo due to the study design. Major reviews and guidelines generally do not recommend Ginkgo as a primary treatment for peripheral neuropathy due to insufficient high-quality evidence. Nonetheless, the use is not based purely on tradition—there is a modest but real scientific rationale, with some clinical data suggesting potential benefit. Overall, the evidence is weak (rated 2/5), and more rigorous, large-scale trials are needed to validate its efficacy and safety for this indication.

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