Evidence supporting the use of: Nicotinamide riboside
For the health condition: Peripheral Neuropathy

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nicotinamide riboside (NR) is a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule essential for cellular metabolism and mitochondrial function. There is growing scientific interest in NR for neurodegenerative conditions, including peripheral neuropathy, because NAD+ levels decline with age and in certain disease states, potentially contributing to nerve dysfunction and degeneration.

Preclinical studies in animal models have shown that boosting NAD+ levels with NR can promote nerve regeneration, reduce axonal degeneration, and improve mitochondrial health in peripheral nerves. For example, studies in mice have demonstrated that NR supplementation can mitigate chemotherapy-induced peripheral neuropathy and diabetic neuropathy, primarily by enhancing neuronal survival and reducing inflammation and oxidative stress.

Human evidence is still emerging and limited. Small pilot clinical trials have investigated NR in the context of neuropathy, with some reporting trends toward improvement in nerve function or pain scores, but these studies generally have small sample sizes, short durations, and sometimes conflicting results. Larger, well-controlled clinical trials are needed to establish efficacy and safety for this indication.

In summary, the use of nicotinamide riboside for peripheral neuropathy is supported by promising preclinical and early clinical evidence, but robust scientific validation in humans is lacking. The current evidence base justifies cautious optimism but not routine clinical use.

More about nicotinamide riboside
More about Peripheral Neuropathy