Evidence supporting the use of: Pine bark
For the health condition: Peripheral Neuropathy

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Pine bark extract, particularly in the form of standardized extracts like Pycnogenol®, has been investigated for its potential role in supporting or treating peripheral neuropathy, especially diabetic neuropathy. The primary active compounds in pine bark—proanthocyanidins (a class of flavonoids)—exhibit antioxidant, anti-inflammatory, and vasodilatory properties. Several small-scale clinical studies and animal models have reported beneficial effects of pine bark extract in reducing symptoms associated with peripheral neuropathy, such as pain, burning sensations, and numbness. For instance, a 2012 randomized clinical trial published in European Review for Medical and Pharmacological Sciences found that patients with diabetic neuropathy given Pycnogenol® showed significant improvements in neuropathic symptoms and microcirculation compared to controls. Other studies have noted reductions in oxidative stress markers and improvements in nerve function.

However, the overall quality and size of these studies are moderate, and more large-scale, well-controlled trials are needed to confirm these effects and establish standardized dosing. While there is a plausible scientific rationale—owing to the antioxidant and vasoprotective effects of pine bark extract—the evidence is not yet robust enough for widespread clinical recommendation. Nonetheless, the current body of research justifies cautious optimism and ongoing investigation into pine bark extract as a supportive therapy for peripheral neuropathy, particularly in diabetic populations.

More about pine bark
More about Peripheral Neuropathy