Evidence supporting the use of: Triacetyluridine
For the health condition: Peripheral Neuropathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Triacetyluridine (TAU) is a modified form of uridine, a nucleoside involved in RNA synthesis and neuronal function. Its use in supporting or treating peripheral neuropathy is primarily based on preclinical and early clinical evidence suggesting that uridine supplementation, particularly in combination with other agents like vitamin B12 and folic acid, may enhance nerve repair and regeneration. Several animal studies have demonstrated that uridine can promote neurite outgrowth, improve mitochondrial function, and support membrane phospholipid synthesis, all of which are relevant to nerve health.

In humans, a few small clinical trials and open-label studies have tested uridine (sometimes as TAU or as part of a combination therapy) in patients with peripheral neuropathy, including diabetic and chemotherapy-induced neuropathy. These studies have reported modest improvements in neuropathic symptoms and nerve conduction parameters compared to placebo. The mechanism is thought to involve enhanced synthesis of neuronal membranes and support for axonal regeneration. However, the overall clinical evidence base remains limited, with small sample sizes, short durations, and some studies lacking rigorous controls.

As of 2024, Triacetyluridine is not universally accepted as a standard therapy for peripheral neuropathy, but there is a moderate level of scientific rationale and some preliminary human data supporting its potential benefit. Larger, well-controlled clinical trials are needed to confirm its efficacy and safety for this indication.

More about Triacetyluridine
More about Peripheral Neuropathy

Other health conditions supported by Triacetyluridine

Memory and Brain Function
Parkinson's Disease
Peripheral Neuropathy

Products containing Triacetyluridine

We currently have no products on Vitabase that contain this ingredient.