Evidence supporting the use of: Vitamin B1 (Sulbutiamine)
For the health condition: Peripheral Neuropathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) developed to increase thiamine levels in the brain and peripheral tissues. Its use for peripheral neuropathy is based on the established role of thiamine deficiency in the development of certain neuropathies, particularly in conditions such as beriberi or chronic alcoholism. There is a moderate body of evidence from clinical studies, primarily in Europe and Japan, supporting the efficacy of thiamine derivatives (including sulbutiamine and benfotiamine) in improving symptoms of peripheral neuropathy, especially diabetic neuropathy. For example, benfotiamine has shown some benefit in randomized controlled trials for diabetic neuropathy, but direct studies on sulbutiamine are fewer and less robust. Some small clinical studies and case reports suggest improvement in neuropathic symptoms with sulbutiamine supplementation, but these findings are not consistently replicated in large-scale, high-quality trials. Major medical guidelines do not currently recommend sulbutiamine as a primary treatment for peripheral neuropathy. The overall scientific evidence is limited but suggests a possible benefit, likely due to enhanced thiamine bioavailability and its role in nerve function. Therefore, while there is a scientific rationale and some supportive evidence, the overall quality and quantity of data remain insufficient for strong recommendations.

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