Evidence supporting the use of: Vitamin B1 (thiamin disulfide)
For the health condition: Peripheral Neuropathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B1 (thiamin), sometimes in the form of thiamin disulfide or benfotiamine, has been investigated for its role in supporting or treating peripheral neuropathy, particularly in diabetic neuropathy. Scientific interest stems from thiamin’s crucial role in glucose metabolism and nerve function. Thiamin deficiency can lead to nerve damage and diseases such as beriberi, which include neuropathic symptoms. Several small clinical studies and some randomized controlled trials have examined thiamin and especially benfotiamine (a fat-soluble derivative with better bioavailability) for peripheral neuropathy, particularly in diabetes. Some studies have shown modest improvements in neuropathic symptoms like pain, numbness, and nerve conduction when using high-dose benfotiamine or thiamin, often in combination with vitamin B6 and B12. However, evidence remains limited and somewhat inconsistent. Most studies are small, short-term, or combine multiple B vitamins, making it difficult to isolate the effects of thiamin alone. Systematic reviews and meta-analyses generally conclude that while there is some preliminary evidence for benefit, high-quality, large-scale clinical trials are lacking, and thiamin should not be considered a stand-alone or primary therapy for peripheral neuropathy except in cases of proven deficiency. Supplementation is justified in individuals with or at risk for thiamin deficiency, but routine use for neuropathy in well-nourished individuals is not strongly supported by current evidence.

More about Vitamin B1 (thiamin disulfide)
More about Peripheral Neuropathy

Other health conditions supported by Vitamin B1 (thiamin disulfide)

Alcoholism
Diabetes
Fatigue
Peripheral Neuropathy
Wasting

Products containing Vitamin B1 (thiamin disulfide)

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