Evidence supporting the use of: Vitamin B12 (cyanacobalamin)
For the health condition: Peripheral Neuropathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 (cyanocobalamin) is scientifically validated for use in the support and treatment of certain types of peripheral neuropathy, particularly those caused by vitamin B12 deficiency. Peripheral neuropathy, defined as damage to the peripheral nerves, can result from multiple etiologies, including metabolic disorders, toxins, infections, and nutritional deficiencies. B12 deficiency is a well-established, reversible cause of neuropathy, typically presenting with symptoms such as numbness, tingling, and weakness, especially in the extremities.

Several clinical studies and case reports have demonstrated that supplementation with vitamin B12 can halt progression and, in some cases, improve neuropathic symptoms in patients with B12 deficiency. The evidence for efficacy is strongest in deficiency-induced neuropathy, with improvements in nerve conduction and symptomatology documented after B12 repletion. However, for neuropathies unrelated to B12 deficiency (e.g., diabetic neuropathy without B12 deficiency), the evidence supporting B12 supplementation is far weaker and largely inconclusive. Meta-analyses and systematic reviews generally recommend B12 supplementation only in deficient individuals.

In summary, vitamin B12 is scientifically justified for treating peripheral neuropathy specifically due to B12 deficiency, with moderate quality evidence (rated 3/5) supporting this indication. Its routine use in other forms of neuropathy without deficiency lacks substantial evidence.

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