Evidence supporting the use of: Vitamin B12 (methylcobalamin)
For the health condition: Peripheral Neuropathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 (methylcobalamin) is supported by scientific evidence for use in some forms of peripheral neuropathy, particularly when neuropathy is caused by B12 deficiency. Methylcobalamin is one of the bioactive forms of B12 involved in nerve health and myelin synthesis. Several clinical studies and reviews indicate that B12 supplementation can alleviate neuropathy symptoms in individuals who are deficient or have suboptimal B12 status. For example, randomized controlled trials have shown improvements in neuropathic pain, nerve conduction, and sensory symptoms in diabetic neuropathy and other neuropathies when treated with methylcobalamin, especially at higher doses.

However, evidence for benefit in peripheral neuropathy not caused by B12 deficiency is less robust. Some studies suggest possible symptomatic improvement in diabetic and idiopathic neuropathy with high-dose methylcobalamin, but results are mixed and often limited by small sample sizes or methodological issues. Guidelines generally recommend B12 supplementation for neuropathy only in cases of demonstrated or suspected deficiency.

In summary, the use of methylcobalamin for peripheral neuropathy is scientifically justified in cases of B12 deficiency, and there is moderate evidence (rated 3 out of 5) for its efficacy in these populations. For other forms of neuropathy, the evidence is weaker and supplementation is not routinely recommended unless deficiency is present.

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