Evidence supporting the use of: Vitamin B3 (various)
For the health condition: Peripheral Neuropathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B3, which includes niacin (nicotinic acid) and niacinamide (nicotinamide), has some scientific rationale for use in peripheral neuropathy, but the evidence is limited and not robust. Peripheral neuropathy can arise from several causes, including diabetes, nutritional deficiencies, toxins, or medications. While vitamin B12 and B6 deficiencies are much more definitively linked to neuropathy, severe niacin deficiency (pellagra) can also cause neurological symptoms, including peripheral neuropathy. Correction of deficiency states with vitamin B3 supplementation can resolve these symptoms; however, this applies specifically to cases of deficiency and not to neuropathy from other causes.

Some small studies and case reports suggest that niacinamide may have neuroprotective properties and could play a role in nerve repair or improvement of symptoms, but these findings are preliminary and not well-established. The majority of clinical guidelines do not recommend vitamin B3 supplementation for peripheral neuropathy unless there is a documented deficiency. Overall, the scientific evidence supporting routine use of vitamin B3 for peripheral neuropathy is weak outside the context of pellagra or clear deficiency, and more research is needed to confirm any broader benefits.

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