Evidence supporting the use of: Vitamin E (tocotrienol unspecified)
For the health condition: Peripheral Neuropathy

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, including tocotrienols (though most studies focus on tocopherol forms), has some scientific evidence supporting its use in peripheral neuropathy, particularly in cases related to vitamin E deficiency or in specific neuropathies such as those associated with diabetes or chemotherapy. Several small clinical studies and case reports suggest that vitamin E supplementation may improve neuropathic symptoms, especially in individuals with low vitamin E levels. For example, vitamin E deficiency is a known cause of neuropathy in rare genetic disorders like abetalipoproteinemia, and supplementation is standard therapy in such cases. Additionally, some research suggests antioxidant properties of vitamin E may help reduce oxidative stress implicated in diabetic neuropathy or chemotherapy-induced peripheral neuropathy (CIPN). However, large-scale, high-quality randomized controlled trials specifically investigating tocotrienols for peripheral neuropathy are lacking. Most data focus on alpha-tocopherol, and results are mixed regarding efficacy in broader populations. Current guidelines do not recommend routine use of vitamin E for peripheral neuropathy except in deficiency states. In summary, there is limited but plausible scientific rationale and some preliminary clinical evidence, primarily for vitamin E in general rather than tocotrienols specifically, but the overall quality and quantity of evidence is modest.

More about Vitamin E (tocotrienol unspecified)
More about Peripheral Neuropathy

Products containing Vitamin E (tocotrienol unspecified)

We currently have no products on Vitabase that contain this ingredient.