Evidence supporting the use of: Cobalt
For the health condition: Pernicious Anemia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Cobalt is scientifically validated as having a role in the treatment of pernicious anemia, but not in its elemental or salt form—rather, as an essential component of vitamin B12 (cobalamin). Pernicious anemia is caused by an inability to absorb vitamin B12 from the gastrointestinal tract due to intrinsic factor deficiency. Historically, before vitamin B12 was isolated, cobalt salts were sometimes administered because it was observed that cobalt could stimulate red blood cell production. However, direct administration of cobalt salts is not the modern standard of care due to toxicity risks and the superior efficacy of vitamin B12 itself.

The scientific underpinning for cobalt’s use is that vitamin B12 contains a central cobalt atom essential for its biological activity. Vitamin B12 supplementation, either by injection or high-dose oral formulations, is the definitive treatment for pernicious anemia. Cobalt by itself is not therapeutically administered for this condition today. The historical use of cobalt salts has been supplanted by purified vitamin B12, which is safe and highly effective. Thus, while cobalt is crucial as a part of vitamin B12, the direct use of cobalt compounds for pernicious anemia is outdated and not recommended.

More about Cobalt
More about Pernicious Anemia

Other health conditions supported by Cobalt

Anemia
Pernicious Anemia

Products containing Cobalt

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