Evidence supporting the use of: Beta-Glucans
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Beta-glucans are naturally occurring polysaccharides found in the cell walls of cereals, bacteria, and fungi. There is scientific evidence supporting their role in modulating the immune system, particularly via the gut-associated lymphoid tissue (GALT), which includes Peyer’s patches. Peyer’s patches are clusters of lymphoid tissue in the small intestine that play a critical role in immune surveillance and initiation of immune responses to gut pathogens.

Research indicates that orally administered beta-glucans can interact with the intestinal mucosa and are taken up by M cells overlying Peyer’s patches. Once internalized, beta-glucans are recognized by pattern recognition receptors (such as Dectin-1) on macrophages and dendritic cells within Peyer’s patches. This interaction triggers a cascade of immune responses, including enhanced production of secretory IgA (sIgA) and the activation of antigen-presenting cells, which can prime systemic and mucosal immunity. Several animal and in vitro studies demonstrate that beta-glucans stimulate the function of Peyer’s patch cells and increase resistance to infections.

While much of the direct evidence comes from preclinical studies, some human studies suggest that oral beta-glucan supplementation can enhance immune markers, though specific direct effects on Peyer’s patches in humans are less well-characterized. Overall, the scientific literature supports a plausible and partially validated mechanism by which beta-glucans support the immune functions associated with Peyer’s patches.

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Products containing Beta-Glucans

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