Evidence supporting the use of: Bifidobacterium animalis lactis
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bifidobacterium animalis lactis is a probiotic bacterium that has been studied for its effects on gut immunity, including its interaction with Peyer’s patches. Peyer’s patches are lymphoid follicles located in the small intestine that play a key role in the immune surveillance of intestinal contents and the generation of immune responses. Several preclinical and clinical studies have indicated that B. animalis lactis can modulate the immune system, in part through interactions with gut-associated lymphoid tissue (GALT) such as Peyer’s patches.

Animal studies have demonstrated that supplementation with B. animalis lactis can increase the number of IgA-producing cells in Peyer’s patches, enhance phagocytic activity, and stimulate the production of anti-inflammatory cytokines. In vitro experiments suggest that B. animalis lactis can promote dendritic cell maturation and modulate T-cell responses within GALT. Some human studies, though limited in size and scope, have reported increased mucosal IgA levels and beneficial modulation of immune markers after ingestion of B. animalis lactis-containing probiotics.

Despite these findings, direct evidence in humans linking B. animalis lactis supplementation specifically to changes in Peyer’s patches is limited, and much of the mechanistic research comes from animal models. Therefore, while there is a scientific basis for its use to support gut immune function and potentially Peyer’s patches, the degree of evidence is moderate rather than robust.

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