Evidence supporting the use of: Fructo-Oligosaccharides (FOS)
For the body system: Peyer’s patches

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fructo-Oligosaccharides (FOS) and Peyer’s Patches: Scientific Evidence

Fructo-oligosaccharides (FOS) are prebiotic fibers commonly found in various plants and are widely recognized for their ability to promote the growth of beneficial gut bacteria. There is some scientific evidence suggesting that FOS can influence the immune system, particularly through interactions with gut-associated lymphoid tissue (GALT) such as Peyer’s patches. These lymphoid follicles are integral to immune surveillance in the intestine.

Several animal studies have shown that dietary FOS can increase the number and activity of immune cells in Peyer’s patches, including IgA-producing cells and dendritic cells. For example, research in rodents indicates that FOS supplementation enhances secretory IgA production, a key immune function localized to Peyer’s patches. Some studies also suggest that FOS may modulate cytokine profiles and support mucosal immunity by promoting the maturation and function of immune cells within these patches.

However, direct clinical evidence in humans is limited, and most supporting studies have been conducted in animal models. The mechanistic link is plausible, given FOS’s established role as a prebiotic and the importance of the gut microbiota in regulating mucosal immunity via Peyer’s patches. Nonetheless, while the scientific rationale exists, the overall level of evidence specifically supporting FOS for Peyer’s patches in humans remains modest.

In summary, FOS is used with some scientific justification to support immune functions involving Peyer’s patches, but high-quality human trials are needed to confirm these effects.

More about Fructo-Oligosaccharides (FOS)
More about Peyer’s patches

Products containing Fructo-Oligosaccharides (FOS)

We currently have no products on Vitabase that contain this ingredient.