Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Inulin is a type of prebiotic fiber found in many plants, such as chicory root, Jerusalem artichoke, and onions. Its primary benefit is to nourish beneficial gut microbiota, which in turn can modulate immune function. Peyer’s patches are small masses of lymphatic tissue found in the small intestine, playing a crucial role in immune surveillance and the generation of immune responses to antigens present in the gut.

Scientific evidence, largely from animal studies and in vitro experiments, indicates that inulin can indirectly support the function of Peyer’s patches. Inulin fermentation by gut bacteria produces short-chain fatty acids (SCFAs), which have been shown to regulate immune responses. Several studies (e.g., Singh et al., 2014; Hosono et al., 2003) have found that dietary inulin increases the number of IgA-producing cells in Peyer’s patches and enhances mucosal immune function. However, direct evidence in humans remains limited. Most research focuses on general gut immune modulation rather than specific effects on Peyer’s patches in people.

Overall, the use of inulin to support immune functions associated with Peyer’s patches is scientifically plausible, supported by preclinical research and mechanistic studies. However, the evidence is not robust or comprehensive in humans, so the rating reflects moderate confidence.

More about inulin
More about Peyer’s patches

Other ingredients that support Peyer’s patches

Other body systems supported by inulin

Products containing inulin

Metagenics Ultra Energy Bar Caramel Sea Salt
Metagenics Ultra Protein Bar Peanut Butter
Metagenics UltraFlora Triplebiotic