Evidence supporting the use of: Lactobacillus kefiri
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus kefiri is a probiotic bacterium commonly found in kefir, a fermented dairy product. There is some scientific evidence suggesting that L. kefiri can influence the immune system, including effects on the gut-associated lymphoid tissue (GALT), of which Peyer’s patches are a crucial component. Peyer’s patches are small masses of lymphatic tissue found in the small intestine and play a central role in mucosal immunity by sampling antigens and initiating immune responses.

Several in vitro and in vivo studies have demonstrated that L. kefiri can modulate immune responses. For instance, research published in Beneficial Microbes (2017) and Frontiers in Immunology (2020) has shown that L. kefiri strains can stimulate the production of cytokines and enhance the activity of immune cells in the intestinal mucosa. Specifically, some studies in mice indicate that administration of L. kefiri leads to increased IgA production and altered cytokine profiles in Peyer’s patches, suggesting enhanced mucosal immune defense.

However, while these findings are promising, most of the evidence comes from animal studies or laboratory experiments, and there is limited direct clinical evidence in humans linking L. kefiri supplementation to enhanced function of Peyer’s patches specifically. Therefore, the scientific support is limited but present, justifying a moderate evidence rating.

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Products containing Lactobacillus kefiri

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