Evidence supporting the use of: Lactobacillus plantarum
For the body system: Peyer’s patches

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus plantarum is a well-studied probiotic bacterium known for its beneficial effects on gut health and the immune system. Peyer's patches are lymphoid tissues in the small intestine that play a critical role in the body’s mucosal immune response. Several animal studies and limited in vitro research suggest that L. plantarum can interact with Peyer’s patches, modulating immune responses. Specifically, L. plantarum has been shown to stimulate the production of immunoglobulin A (IgA) and influence dendritic cell and T cell activation within Peyer’s patches, thereby promoting mucosal immunity (Wells et al., 2011; Wang et al., 2016). These effects are thought to occur through the recognition of microbial-associated molecular patterns by immune cells in the patches. However, direct high-quality human clinical trials explicitly linking L. plantarum supplementation to improved Peyer’s patches function or immunity are lacking. Most of the supporting data come from animal models or ex vivo studies. While these findings suggest a potential mechanism of action, the evidence is not robust enough to warrant a high rating. Thus, the use of L. plantarum to support Peyer’s patches is based on preliminary scientific evidence, but more rigorous human studies are needed to confirm its efficacy and specific effects on this aspect of the immune system.

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