Evidence supporting the use of: Lactobacillus sakei
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactobacillus sakei is a species of lactic acid bacteria commonly found in fermented foods such as kimchi and certain types of sausages. In terms of supporting the Peyer’s patches—specialized immune structures in the small intestine that play a major role in gut immunity—there is scientific evidence suggesting that L. sakei may have immunomodulatory effects relevant to this body system. Several in vitro and in vivo studies have demonstrated that L. sakei can enhance the production of secretory IgA and modulate cytokine production, both of which are important functions of Peyer’s patches. For example, research published in Beneficial Microbes (2013) and Frontiers in Microbiology (2017) describes how certain L. sakei strains stimulate dendritic cells and T cells in the gut-associated lymphoid tissue, including Peyer’s patches, leading to enhanced mucosal immunity.

However, direct clinical evidence in humans remains limited, and most of the evidence comes from animal models or cell culture studies. The ability of L. sakei to interact with and stimulate Peyer’s patches is biologically plausible, but further clinical research is needed to confirm its efficacy and relevance in human health. Thus, while the use of L. sakei for supporting Peyer’s patches function is grounded in scientific exploration, the strength of evidence is moderate.

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Products containing Lactobacillus sakei

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