Evidence supporting the use of: Lactobacillus (unspepcified)
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactobacillus species, as a group of probiotic bacteria, have been investigated for their effects on gut-associated lymphoid tissue (GALT), which includes Peyer’s patches. Peyer’s patches are important immune structures in the small intestine, playing a key role in initiating immune responses to gut pathogens and maintaining mucosal immunity. Several studies in animal models and some in humans suggest that certain Lactobacillus strains can stimulate or modulate immune functions through their interaction with Peyer’s patches. For example, research has shown that oral administration of specific Lactobacillus strains can promote the maturation of dendritic cells and the production of immunoglobulin A (IgA) in Peyer’s patches, thereby enhancing mucosal immunity.

However, most of the evidence comes from preclinical studies using specific strains (e.g., Lactobacillus casei, Lactobacillus rhamnosus). The data for “unspecified” Lactobacillus is less robust because effects are often strain-dependent, and not all Lactobacillus species or strains exhibit the same immunomodulatory properties. There are limited clinical studies directly linking generic Lactobacillus supplementation to improved function or health of Peyer’s patches in humans. Thus, while there is scientific plausibility and preclinical evidence for the role of certain Lactobacillus strains in supporting Peyer’s patches and mucosal immunity, the evidence is moderate and not comprehensive for all strains or for unspecified Lactobacillus.

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