Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactococcus lactis is a lactic acid bacterium commonly used in the dairy industry and as a probiotic. Its relationship to the immune system, particularly the Peyer’s patches—which are lymphoid follicles in the small intestine that play a crucial role in gut immunity—has been explored in scientific research. Several studies indicate that L. lactis can interact with gut-associated lymphoid tissue (GALT), including Peyer’s patches, to modulate immune responses. Animal models have demonstrated that oral administration of L. lactis can increase the number and activity of immune cells in Peyer’s patches, enhance IgA production, and influence cytokine expression, suggesting an immunomodulatory effect. Additionally, L. lactis has been used as a vehicle for delivering antigens or therapeutic molecules to Peyer’s patches due to its ability to survive transit through the gastrointestinal tract and interact with intestinal mucosa. However, while some clinical and preclinical studies support these findings, the evidence is not yet robust or extensive enough to warrant the highest confidence rating, and most data come from animal or in vitro studies rather than large human trials. Therefore, the use of L. lactis to support Peyer’s patches and gut immunity is scientifically plausible and supported by moderate experimental evidence, but further research—especially in humans—is needed for strong validation.

More about lactococcus lactis
More about Peyer’s patches

Other ingredients that support Peyer’s patches

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