Evidence supporting the use of: Larch arabinogalactan
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Larch arabinogalactan is a polysaccharide derived from the wood of the larch tree (Larix spp.). Its use for immune support, including effects on the Peyer’s patches (specialized lymphoid follicles in the small intestine that play a key role in gut-associated immune responses), has been investigated in several scientific studies. Arabinogalactan is known to have prebiotic effects, stimulating the growth of beneficial gut bacteria, which can indirectly influence immune function. Some in vitro and animal studies have shown that arabinogalactan can enhance the activity of natural killer cells and macrophages, and may increase the production of short-chain fatty acids that are beneficial for gut health.

With respect to Peyer’s patches specifically, there is limited direct evidence. Some animal studies suggest that dietary fibers like arabinogalactan can interact with gut-associated lymphoid tissue, including Peyer’s patches, potentially enhancing mucosal immunity. However, human clinical data directly linking larch arabinogalactan supplementation to improved function or health of Peyer’s patches are sparse. Most human trials have focused on general immune parameters (like reduced incidence of common cold or increased antibody response), not directly on Peyer’s patches.

In summary, while there is some scientific rationale and limited preclinical evidence for larch arabinogalactan’s potential to modulate immune responses involving Peyer’s patches, the direct evidence in humans is not strong, warranting a modest evidence rating.

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Products containing Larch arabinogalactan

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