Evidence supporting the use of: Resistant Starch
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Resistant starch is a type of dietary fiber that escapes digestion in the small intestine and reaches the colon, where it is fermented by gut microbiota. Scientific research has shown that resistant starch can positively modulate the gut-associated lymphoid tissue (GALT), which includes Peyer’s patches—specialized immune structures in the small intestine that sample antigens and help regulate immune responses. Studies in both animals and humans have found that fermentation of resistant starch produces short-chain fatty acids (SCFAs), especially butyrate, which have immunomodulatory effects.

Animal studies have demonstrated that diets high in resistant starch can increase the number and activity of immune cells in Peyer’s patches, such as IgA-producing B cells, and may enhance the mucosal immune response. Some research suggests that resistant starch can improve the integrity of the gut barrier and modulate systemic and mucosal immunity, potentially reducing inflammation and susceptibility to infections. However, while these effects on Peyer’s patches are promising, most of the evidence comes from animal models; human studies are fewer and often focus on general gut health rather than specifically on Peyer’s patches.

In summary, there is scientific evidence—primarily from preclinical studies—supporting the use of resistant starch to support the immune functions associated with Peyer’s patches. However, the direct evidence in humans is limited, so the strength of evidence is moderate.

More about Resistant Starch
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Products containing Resistant Starch

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