Evidence supporting the use of: Hyaluronidase
For the health condition: Phlebitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hyaluronidase is an enzyme that hydrolyzes hyaluronic acid, thereby increasing tissue permeability and facilitating the diffusion of injected substances or fluids. Its use in the context of phlebitis (inflammation of the veins, often due to intravenous therapy or extravasation) is primarily based on its ability to enhance absorption and dispersion of infiltrated solutions, especially when irritant or vesicant drugs have leaked into surrounding tissues. Several case reports and small studies from the mid-20th century describe the use of hyaluronidase to treat extravasation injuries, which can be associated with phlebitis, by reducing local inflammation, edema, and tissue damage. However, robust clinical trials specifically evaluating hyaluronidase for the treatment of phlebitis are lacking. Most evidence comes from its use in extravasation management, especially with drugs like vinca alkaloids, not for primary phlebitis without extravasation. Guidelines from organizations such as the Infusion Nurses Society mention hyaluronidase as an option for some types of extravasation but do not specifically endorse it for standard phlebitis. Thus, while there is some scientific rationale and limited clinical use for specific cases related to extravasation-induced phlebitis, the overall evidence base is limited and primarily extrapolated from related but not identical clinical scenarios.

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