Evidence supporting the use of: Leucoanthocyanins
For the health condition: Phlebitis

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Leucoanthocyanins, a class of flavonoids also known as proanthocyanidins, have been traditionally used in Europe and some other regions for the management of venous insufficiency and related symptoms, including phlebitis. The rationale behind their use stems from their presumed ability to strengthen capillary walls, reduce capillary permeability, and exert antioxidant effects, which could theoretically help in conditions characterized by inflammation and weakness of blood vessels, such as phlebitis. In traditional medicine, particularly in phytotherapy, extracts from plants rich in leucoanthocyanins (such as grape seeds and pine bark) have been used to alleviate symptoms of venous disorders.

However, scientific evidence specifically supporting the use of leucoanthocyanins in treating phlebitis is limited. Most available studies focus on chronic venous insufficiency and related symptoms (e.g., edema, heaviness, and microcirculation), rather than acute vein inflammation (phlebitis). A few clinical trials and reviews suggest some benefit of proanthocyanidins for venous tone and capillary strength, but robust, high-quality data directly addressing their effectiveness in phlebitis are lacking. Thus, while their use is grounded in tradition and supported by some indirect scientific rationale, the evidence base remains modest, meriting a rating of 2 out of 5.

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