Evidence supporting the use of: Ruscogenin
For the health condition: Phlebitis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ruscogenin and Its Use in Phlebitis

Ruscogenin is a steroidal sapogenin found in the rhizomes of Ruscus aculeatus (Butcher’s broom), a plant traditionally used in Europe for the management of venous disorders. Scientific interest in ruscogenin stems from its anti-inflammatory and vasoconstrictive properties. Several preclinical studies have demonstrated that ruscogenin can reduce vascular permeability, inhibit leukocyte adhesion, and decrease the release of pro-inflammatory cytokines—mechanisms relevant to the pathophysiology of phlebitis (an inflammation of the veins).

Animal models of thrombophlebitis and venous insufficiency have shown that ruscogenin reduces edema and improves vascular tone. Some small-scale clinical trials and observational studies on Ruscus aculeatus extracts (which contain ruscogenin) have reported improvements in symptoms related to chronic venous insufficiency, such as swelling and discomfort, but direct, high-quality clinical evidence specifically for phlebitis is limited. The European Medicines Agency notes the traditional and supportive scientific use of Butcher’s broom for venous conditions, yet acknowledges the paucity of robust, randomized controlled trials.

In summary, while there is a plausible pharmacological basis and some supportive experimental data for ruscogenin’s use in phlebitis, the clinical evidence remains limited and not definitive. Its use is better substantiated for general venous insufficiency rather than acute phlebitis, warranting a moderate evidence rating.

More about Ruscogenin
More about Phlebitis

Products containing Ruscogenin

We currently have no products on Vitabase that contain this ingredient.